1049 Outcomes After Proximal Femoral Replacements in Metastatic Femoral Disease. A Systematic Review and Meta-Analysis

Abstract Aim The aim of the study was to assess outcomes after a proximal femoral replacement (PFR). More PFRs are being performed in accordance with British Orthopaedic Oncology Society (BOOS) best practice guidance 2016. population studied patients metastatic disease actual or impending fractures. intervention and comparator were PFR intra-medullary nailing (IMN) respectively. primary outcome hospital readmission rate (all cause). Secondary reoperation cause, infection) dislocation rate. Method A literature search Medline, Embase, Web Science Cochrane Library. strategy combined free MeSH terms related (e.g., “femoral neoplasms” OR “pathological fracture”), “osteosynthesis” “surgery” “proximal ”). To pool data studies Freeman–Tukey double arcsine transformation used. Readmission rates generated based on complications requiring absolute admission. Results After exclusions, provided 12 studies. pooled cause) 0.08 (95% CI 0.04 - 0.12) (Figure 2). cause), for infection 0.05 0.03 – 0.08), 0.01 0.00 0.04) 0.02 0.05) Conclusions Following disease, have low reoperation. Compared IMN, reoperations deep dislocations. major complication IMNs metalwork fatigue failure is overcome use PFRs.